The advantages of choosing TissuGlu®

TissuGlu was shown in clinical trials to offer many benefits over drains.1,2

93% of patients receiving TissuGlu were drain-free93% of patients receiving TissuGlu were drain-free

of TissuGlu patients recovered drain-free

TissuGlu provided
78%FEWER4 times lower
cumulative days of invasive treatment vs drains2
1.6 days with TissuGlu

days with TissuGlu

7.3 days with drains

days with drains

Ability to get back to normal activities faster

The TissuGlu group had
4XLOWER4 times lower
total wound drainage vs drains2
TissuGlu provided a
73%REDUCTION4 times lower
in fluid-related
invasive treatment1

At study end, 100% of the control group (drains) had invasive postoperative drain removal. In contrast, 93% of the patients in the TissuGlu group required minor to no invasive treatment.

  Invasive Treatments: Control Group (Standard of Care - With Drains) 100% of patients were treated with drains at time of surgery

  Invasive Treatments: TissuGlu Group (TissuGlu Only - No Drains) 100% of patients had no drains at time of surgery

  No Invasive Treatments Required

Request Information

Whether you’re ready to have your tummy tuck or just thinking about it, we have information you can use to help you decide what kind of tummy tuck experience you’d like to have

Find a Drain-Free Certified Physician

A Drain-Free Certified surgeon may make all the difference. Find a Drain-Free Certified physician near you

References: 1. Hunstad JP, Michaels J, Burns AJ, et al. A prospective, randomized, multicenter trial assessing a novel lysine-derived urethane adhesive in a large flap surgical procedure without drains. Aesthetic Plast Surg. 2015;39(4):616-624. 2. Data on file, Cohera Medical, Inc.

Important TissuGlu® Surgical Adhesive Safety Information


TissuGlu® Surgical Adhesive is indicated for the approximation of tissue layers where subcutaneous dead space exists between the tissue plane in abdominoplasty.


Do not use in patients with known or suspected allergies to urethane-based or isocyanate-containing products.


  • Do not use TissuGlu® Surgical Adhesive in patients who have had prior exposure to TissuGlu®. Immunological response associated with repeat TissuGlu® exposure has not been studied.
  • The effectiveness for the treatment of patients with BMI > 28 has not been established. Higher BMI patients have a propensity for fluid accumulation and may have an increased risk of seroma formation.
  • Effectiveness was not observed in weight loss patients undergoing abdominoplasty. Weight loss patients have a propensity for fluid accumulation and may have an increased risk of seroma formation and aspiration.

TissuGlu® may reduce the need for drains after surgery. By using TissuGlu® instead of drains, you may:

  • Return to normal activities more quickly
  • Experience less discomfort and pain than when drains are used
  • Have fewer invasive treatments for fluid management. The results showed that 73% of TissuGlu® patients had no treatments after surgery. However, some patients did require additional invasive treatments including reinsertion of drains.

Clinical studies were performed using TissuGlu®. There were no increased safety risks with the use of TissuGlu® than when drains were used. Potential complications associated with the use of the device and the tummy tuck procedures include seroma (fluid) formation. These complications may require treatments such as drain placement and/or fluid removal by needle, which may be performed in the operating room. Additional potential complications include wound healing issues, rash/redness, surgical site or incision infection, scarring, hematoma (bruise or swelling), incision separation, and immunological reaction.

Safety Information:
For full safety information please visit, contact your doctor, or call Cohera Customer Support at 1-800-641-7458.

TissuGlu® Surgical Adhesive is currently approved for sale in the United States for the approximation of tissue layers where subcutaneous dead space exists between the tissue planes in abdominoplasty. TissuGlu® Surgical Adhesive received European CE Mark in 2011, where it is approved for large flap surgical procedures such as abdominoplasty. TissuGlu® Surgical Adhesive is not approved for sale in any other region. Any questions related to the indication for use should be directed to your Cohera Medical Account Manager or to Cohera Medical Corporate Clinical Affairs. Refer to the complete TissuGlu® Surgical Adhesive Directions for Use for prescribing and usage information.